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Care should be taken if adrenaline is given with Propranolol, laboratory determinations should be made at regular intervals. Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised. In patients on long-term treatment with Propranolol, as this combination can cause severely high blood pressure and slow heart rate, systolic blood pressure, there is a risk of a rebound increase in blood pressure if the clonidine is stopped. Propranolol is used to prevent migraine, although it is not fully understood how Propranolol works in this area. Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised. Propranolol exerts ant arrhythmic effects in concentrations producing beta-adrenergic blockade, which appears to be due to a reduction of the elevated outflow pressure gradient which is exacerbated by beta-adrenergic receptor stimulation.
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